England's first outing since the World Cup, and first with Wayne Rooney as captain, sees them face Norway at Wembley.
A disappointing showing in Brazil over the summer saw the Three Lions sent packing at the group stage with just one point to show for their efforts.
Since then, vastly-experienced figures such as Frank Lampard and skipper Steven Gerrard have announced their international retirement.
Roy Hodgson is now charged with the task of reshaping the squad and building towards Euro 2016.
European Qualifiers get underway next week, with a trip to Switzerland first up for England on Monday, so they have just 90 minutes in which to ready themselves for that campaign.
Hodgson would appear to be putting his faith in youth, with the starting XI he has named to face Norway on Wednesday including five players under the age of 22.
He has gone with Joe Hart in goal, Leighton Baines at left-back, Phil Jones and Gary Cahill at the heart of the back four and John Stones handed a first senior start on the right.
Alex Oxlade-Chamberlain, Jack Wilshere, Jordan Henderson and Raheem Sterling will look to control the midfield and provide the creative spark for strike pair Rooney and Daniel Sturridge.
Rooney will be hoping that he can mark his bow as newly-appointed national skipper, having previously taken the armband as cover for absent colleagues, with an assured display and a 41st goal for his country which would take him clear in fourth place on the all-time scorers list.
He will also be looking to preserve Englands unbeaten record against Norway on home soil although their last encounter in London was 20 years ago.
History suggests that fixtures between the two sides tend to be tight affairs, with only one goal netted in their last three meetings with Ashley Young on target in a pre-European Championship friendly in May 2012.
The lowest attendance for an international at Wembley is expected in midweek, but the game offers an opportunity for England to start righting a few wrongs and prove to the public that a bright future lies ahead.
Team news
New Arsenal signing Danny Welbeck is a doubt for England, while Newcastle United's Jack Colback misses out on the chance to make his debut.
Forward Welbeck picked up a knock in training and is unlikely to be risked, while midfielder Colback is unavailable because of a minor injury suffered in Newcastle's 3-3 draw with Crystal Palace.
Hodgson has included three other uncapped newcomers alongside Colback in his squad, with Calum Chambers, Fabian Delph and Danny Rose making the cut.
Chelsea defender Cahill and Arsenal midfielder Oxlade-Chamberlain took part in a recovery session on Monday after sustaining minor injuries while playing for their clubs at the weekend, but West Bromwich Albion goalkeeper Ben Foster has been forced to return to his club for treatment after sustaining a thumb injury on Tuesday.
Norway - who are 53rd in the FIFA world rankings, 33 spots below England in 20th have a few familiar faces within their ranks.
Norwich City midfielder Alexander Tettey, Celtics Stefan Johansen, Cardiff Citys Mats Moller Daehli and Blackburn Rovers striker Joshua King have all been called upon by coach Per-Mathias Hogmo, along with former Ewood Park winger Morten Gamst Pedersen.
There is, however, no place for 15-year-old sensation Martin Odegaard who was heavily linked with Manchester United before the summer transfer window closed with the youngster having to wait for his second senior cap.